The Effect of Monosodium Glutamate on Estradiol Levels in Pregnant Rats
Keywords:
Estradiol, MSGAbstract
Monosodium glutamate (MSG) is a form of the glutamic acid salt. The purpose of this study to analyze the effect of MSG on estrogen levels in pregnant rats. This research is an experimental study was conducted at January in the Biomedical Laboratory of the Faculty of Medicine, Andalas University, Padang. Total of samples consist of 18 pregnant Wistar rats which were divided into three groups, namely control, treatment one and treatment two. Blood sampling and surgery were performed on day 20 to assess male estrogen levels. Estrogen levels were measured by using the One Way ANOVA. There were significant differences on serum estrogen levels between the control group and treatment group one (p = 0.012) and treatment two (p <0.01) and between treatment group one and treatment group two (p <0.001).The conclusion, there is an effect of MSG on estrogen levels in pregnant rats.
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References
Food And Agriculture Organization. Amino acid content of foods and biological data on protein. http://fao.org/3/AC854T/AC854T00.htm, 1970,retrieved September 20, 2019.
Kurtanty D, Faqih DM, Upa NP. Review monosodium glutamat. Ikatan Dokter Indonesia. Jakarta. p.120, 2018.
Peraturan Menteri Kesehatan Republik Indonesia. Tentang bahan tambahan makanan. http://hukum.unsrat.ac.id/men/menkes_1168_1999.pdf. 1988. Retrieved Agustus, 15, 2019.
Rothman SM. The neurotoxicity of excitatory amino acids is produced by passive chloride influx. Journal of Neuroscience. Vol 5, No 6, Page 1483-1489.1985.
Danbolt NC. Glutamat uptake. Progres in Neurobiology. Vol. 65, page 1-105.2001
Schouboe A, Bak LK, Waagepetersen HS. Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamat and GABA. Frontiers in Endocrinology. Vol. 4, Page 1-11. 2013.
Oladipo IC, Adebayo EA, Kuye OM. Effect of monosodium glutamat in ovaries of female Sprague dewley rats. International Journal Microbiology and Applied Science. Vol. 4, No.5. Page 737-745. 2015.
Iamsaard S, Sukhorum W, Samrid R, Yimde J, Kanla P, Hipkaeo W et al. The sensitivity of male reproductive organ to monosodium glutamat. Medica Academica. Vol 43, No 1. Page 3-9. 2014.
Okoye CN, Ochiogu LS, Onah CE.The effect of monosodium glutamat administration of thereproduction and serum biochemistry of adult male rabbits. Veterinary Medicina. Vol. 61. No. 3. Page 141-147. 2016.
Eweka AO, Eweka A, Om’iniabohs FAE. Histological studies of the effect of monosodium glutamat of the fallopian tubes of adult female wistar rats. North American Journal of Medical Sciences. Vol 2. No, 3. Page 146-149. 2010.
Obochi GO, Malu SP, Abang MO, Alozie Y, Iyam MA. Effect of garlic on monosodium glutamat induced fibroid in wistar rats. Pakistan Journal of Nutrition. Vol. 8. No. 7. Page 979-976. 2009.
Tagliaferri M, Cohen I, Tripathy D. Kanker Payudara : Cara Pengobatan Alternatif, PT Indeks, Jakarta. p, 23, 2007.
Mondal M, Sarkar K, Nath PN, Paul G. Monosodium glutamat suppresses the female reproductive function by imparing the function of ovary and uterus in rat. Environmental Toxicology. Page. 1-11. 2017.
Nwajei JC, Onuoha SC, Essien EB. Effect of oral administration of selected food seasonings consumed in Nigeria on some sex hormones of wistar albino rats. Journal of Biotechnology and Biochemistry. Vol. 1, No 5, page. 15-21. 2015.
