Effects of vitamin d supplementation on type 2 diabetes mellitus patients
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Feb 29, 2024
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Abstract
In Indonesia, around 10.9% of the population has diabetes according to the 2018 basic health research data. It is important for people with diabetes to receive proper treatment to prevent the condition from getting worse. Recently, there have been studies suggesting that taking vitamin D supplements can help improve diabetes. This research aims to explore whether vitamin D supplementation can indeed help control type 2 diabetes mellitus. The approach employed in this investigation entails conducting a comprehensive analysis of existing literature, where relevant articles published in the past 10 years were analyzed based on specific keywords. After finding the appropriate literature, the writing process began. Vitamin D is a substance that acts like a hormone and can increase insulin production in the body. Lot of evidence have shown that taking vitamin D supplements can lower fasting plasma glucose levels, improve insulin resistance, and reduce HbA1c levels when given in high doses over a short period of time. Vitamin D deficiency has also been linked to poor glycemic control in type 2 diabetes mellitus, leading to higher HbA1c levels. Based on the findings from the literature review, it can be concluded that vitamin D supplementation is effective in treating type 2 diabetes mellitus, with a minimum daily dose of 1000 IU. Overall, the evidence suggests that vitamin D supplementation can be a valuable addition to the management of type 2 diabetes mellitus, potentially improving outcomes and overall health in affected individuals. Further research is needed to fully understand the mechanisms behind these benefits and to determine the most effective dosages and treatment protocols.
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How to Cite
Al Aziz, S. A. and Novitasari, D. (2024) “Effects of vitamin d supplementation on type 2 diabetes mellitus patients”, Science Midwifery, 11(6), pp. 971-977. doi: 10.35335/midwifery.v11i6.1413.
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Wenclewska, S., Szymczak-Pajor, I., Drzewoski, J., Bunk, M., & Śliwińska, A. (2019). Vitamin D Supplementation Reduces Both Oxidative DNA Damage and Insulin Resistance in the Elderly with Metabolic Disorders. International Journal of Molecular Sciences, 20(12). https://doi.org/10.3390/IJMS20122891
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WHO. (2023). Diabetes. World Health Organization.
Wu, Chunfeng, Song, Y., & Wang, X. (2023). Vitamin D Supplementation for the Outcomes of Patients with Gestational Diabetes Mellitus and Neonates: A Meta-Analysis and Systematic Review. International Journal of Clinical Practice, 2023. https://doi.org/10.1155/2023/1907222
Wu, Chunhua, Qiu, S., Zhu, X., & Li, L. (2017). Vitamin D supplementation and glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Metabolism, 73, 67–76. https://doi.org/10.1016/J.METABOL.2017.05.006
Bikle, D. D. (2021). Vitamin D: Production, Metabolism and Mechanisms of Action. Endotext.
CDC. (2022). What Causes Type 2 Diabetes | Diabetes | CDC. Centers for Disease Control and Prevention (CDC).
Chauhan, K., Shahrokhi, M., & Huecker, M. R. (2023). Vitamin D. StatPearls.
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., & Carmeliet, G. (2015). Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects. Physiological Reviews, 96(1), 365–408. https://doi.org/10.1152/PHYSREV.00014.2015/ASSET/IMAGES/LARGE/Z9J0011627520010.JPEG
Dominguez, L. J., Farruggia, M., Veronese, N., & Barbagallo, M. (2021). Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites, 11(4). https://doi.org/10.3390/METABO11040255
Farahmand, M. A., Daneshzad, E., Fung, T. T., Zahidi, F., Muhammadi, M., Bellissimo, N., & Azadbakht, L. (2023). What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails. BMC Endocrine Disorders, 23(1), 1–14. https://doi.org/10.1186/S12902-022-01209-X/FIGURES/4
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020). Pathophysiology of type 2 diabetes mellitus. In International Journal of Molecular Sciences (Vol. 21, Issue 17, pp. 1–34). https://doi.org/10.3390/ijms21176275
Galușca, D., Popoviciu, M. S., Babeș, E. E., Vidican, M., Zaha, A. A., Babeș, V. V., Jurca, A. D., Zaha, D. C., & Bodog, F. (2022). Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto’s Disease and Grave’s Disease), Diabetes Mellitus and Obesity. Medicina, 58(2). https://doi.org/10.3390/MEDICINA58020194
Genuth, S. M., Palmer, J. P., & Nathan, D. M. (2018). Classification and Diagnosis of Diabetes. Diabetes in America, 3rd Edition, 2(4), 1–39.
Goyal, R., Singhal, M., & Jialal, I. (2023). Type 2 Diabetes. Exercise Management for Referred Medical Conditions, 223–252. https://doi.org/10.4324/9781315102399-12
Hu, Z., Chen, J., Sun, X., Wang, L., & Wang, A. (2019). Efficacy of vitamin D supplementation on glycemic control in type 2 diabetes patients: A meta-analysis of interventional studies. Medicine, 98(14). https://doi.org/10.1097/MD.0000000000014970
Ismail, L., Materwala, H., & Al Kaabi, J. (2021). Association of risk factors with type 2 diabetes: A systematic review. Computational and Structural Biotechnology Journal, 19, 1759. https://doi.org/10.1016/J.CSBJ.2021.03.003
Karonova, T., Stepanova, A., Bystrova, A., & Jude, E. B. (2020). High-Dose Vitamin D Supplementation Improves Microcirculation and Reduces Inflammation in Diabetic Neuropathy Patients. Nutrients, 12(9), 1–10. https://doi.org/10.3390/NU12092518
Khan, M. U., Gautam, G., Jan, B., Zahiruddin, S., Parveen, R., & Ahmad, S. (2022). Vitamin D from Vegetable VV Sources: Hope for the Future. Phytomedicine Plus, 2(2), 100248. https://doi.org/10.1016/J.PHYPLU.2022.100248
Lee, C. J., Iyer, G., Liu, Y., Kalyani, R. R., Bamba, N., Ligon, C. B., Varma, S., & Mathioudakis, N. (2017). The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies. Journal of Diabetes and Its Complications, 31(7), 1115. https://doi.org/10.1016/J.JDIACOMP.2017.04.019
Li, X., Liu, Y., Zheng, Y., Wang, P., & Zhang, Y. (2018). The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis. Nutrients, 10(3). https://doi.org/10.3390/NU10030375
Md Isa, Z., Amsah, N., & Ahmad, N. (2023). The Impact of Vitamin D Deficiency and Insufficiency on the Outcome of Type 2 Diabetes Mellitus Patients: A Systematic Review. Nutrients, 15(10), 2310. https://doi.org/10.3390/NU15102310/S1
Ohyama, Y., & Shinki, T. (2023). Calcitriol. Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, 548,e97A-1-550,e97A-5. https://doi.org/10.1016/B978-0-12-801028-0.00236-1
Rafiq, S., & Jeppesen, P. B. (2021). Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations. Nutrients, 13(6). https://doi.org/10.3390/NU13061742
Riskesdas. (2018). Hasil Utama Riskesdas. Kementerian Kesehatan Republik Indonesia.
Sapra, A., & Bhandari, P. (2023). Diabetes. StatPearls.
Sizar, O., Khare, S., Goyal, A., & Givler, A. (2023). Vitamin D Deficiency. Endocrinology and Diabetes: A Problem Oriented Approach: Second Edition, 245–256. https://doi.org/10.1007/978-3-030-90684-9_23
Soelistijo, S. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. Global Initiative for Asthma, 46.
Soelistijo, S. A., & et al. (2019). Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia. PB Perkeni, 133.
Ubaeed, H. A., & Marjani, A. (2023). Impact of vitamin D elements in insulin sensitivity in type 2 diabetes mellitus (DM2). Materials Today: Proceedings, 80, 2638–2641. https://doi.org/10.1016/J.MATPR.2021.07.004
Wang, M., Zhou, T., Li, X., Ma, H., Liang, Z., Fonseca, V. A., Heianza, Y., & Qi, L. (2020). Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank Study. Diabetes Care, 43(11), 2776. https://doi.org/10.2337/DC20-1109
Wenclewska, S., Szymczak-Pajor, I., Drzewoski, J., Bunk, M., & Śliwińska, A. (2019). Vitamin D Supplementation Reduces Both Oxidative DNA Damage and Insulin Resistance in the Elderly with Metabolic Disorders. International Journal of Molecular Sciences, 20(12). https://doi.org/10.3390/IJMS20122891
WHO. (2020). The top 10 causes of death. World Health Organization.
WHO. (2023). Diabetes. World Health Organization.
Wu, Chunfeng, Song, Y., & Wang, X. (2023). Vitamin D Supplementation for the Outcomes of Patients with Gestational Diabetes Mellitus and Neonates: A Meta-Analysis and Systematic Review. International Journal of Clinical Practice, 2023. https://doi.org/10.1155/2023/1907222
Wu, Chunhua, Qiu, S., Zhu, X., & Li, L. (2017). Vitamin D supplementation and glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. Metabolism, 73, 67–76. https://doi.org/10.1016/J.METABOL.2017.05.006