Antioxidant activity of brown algae extract (Sargassum sp): A review
##plugins.themes.academic_pro.article.sidebar##
Published
Feb 28, 2024
Download
Statistic
Downloads
Download data is not yet available.
##plugins.themes.academic_pro.article.main##
Abstract
Free radicals are compounds that trigger oxidative stress and harm human health. Uncontrolled oxidative stress causes several degenerative diseases. Antioxidants are needed to prevent or reduce oxidative stress. One of the plants with a high content of antioxidant compounds is brown algae (Sargassum sp). The study aimed to examine Sargassum sp.'s antioxidant activity, which is expressed in the IC50 value using the DPPH method as measured by a UV-Vis spectrophotometer. It is a narrative review, with literature searches from the Science Direct, Pubmed, and Google Scholar databases. The results showed that the methanol extract of Sargassum sp. has strong antioxidant activity consisting of phenolic compounds, flavonoids, and carotenoids. This review concludes that Sargassum sp extract has antioxidant activity.
##plugins.themes.academic_pro.article.details##
How to Cite
Riwanti, P., Mahmiah, M. and Juniar, K. (2024) “Antioxidant activity of brown algae extract (Sargassum sp): A review”, Science Midwifery, 11(6), pp. 962-970. doi: 10.35335/midwifery.v11i6.1420.
References
Arsianti, A., Bahtiar, A., Wangsaputra, V. K., Azizah, N. N., Fachri, W., Nadapdap, L. D., Fajrin, A. M., Tanimoto, H., & Kakiuchi, K. (2020). Phytochemical composition and evaluation of marine algal Sargassum polycystum for antioxidant activity and in vitro cytotoxicity on hela cells. Pharmacognosy Journal, 12(1), 88–94. https://doi.org/10.5530/pj.2020.12.14
Baek, S. H., Cao, L., Jeong, S. J., Kim, H. R., Nam, T. J., & Lee, S. G. (2021). The Comparison of Total Phenolics, Total Antioxidant, and Anti-Tyrosinase Activities of Korean Sargassum Species. Journal of Food Quality, 2021. https://doi.org/10.1155/2021/6640789
Balasubramaniam, V., June Chelyn, L., Vimala, S., Mohd Fairulnizal, M. N., Brownlee, I. A., & Amin, I. (2020). Carotenoid composition and antioxidant potential of Eucheuma denticulatum, Sargassum polycystum and Caulerpa lentillifera. Heliyon, 6(8). https://doi.org/10.1016/j.heliyon.2020.e04654
Catarino, M. D., Silva-Reis, R., Chouh, A., Silva, S., Braga, S. S., Silva, A. M. S., & Cardoso, S. M. (2023). Applications of Antioxidant Secondary Metabolites of Sargassum spp. Marine Drugs, 21(3), 172.
de Menezes, B. B., Frescura, L. M., Duarte, R., Villetti, M. A., & da Rosa, M. B. (2021). A critical examination of the DPPH method: Mistakes and inconsistencies in stoichiometry and IC50 determination by UV–Vis spectroscopy. Analytica Chimica Acta, 1157. https://doi.org/10.1016/j.aca.2021.338398
Edison, E., Diharmi, A., Ariani, N. M., & Ilza, M. (2020). Komponen bioaktif dan aktivitas antioksidan ekstrak kasar Sargassum plagyophyllum. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(1), 58–66.
Firdaus, M. (2013). Antioxidant Activity Index of Brown Seaweed (Sargassum aquifolium) Extract. Indonesian Journal of Fishery Product Processing, 16(1), 42–47.
Gazali, M., Zamani, N., Nurjanah, N., Zulfadhli, Z., & Safutra, E. (2018). Eksplorasi potensi senyawa bioaktif makroalga laut Sargassum sp asal Pesisir Aceh Barat sebagai agen antioksidan. Journal of Aceh Aquatic Sciences, 1(1).
Jimenez-Lopez, C., Pereira, A. G., Lourenço-Lopes, C., Garcia-Oliveira, P., Cassani, L., Fraga-Corral, M., Prieto, M. A., & Simal-Gandara, J. (2021). Main bioactive phenolic compounds in marine algae and their mechanisms of action supporting potential health benefits. Food Chemistry, 341. https://doi.org/10.1016/j.foodchem.2020.128262
Kaczorová, D., Karalija, E., Dahija, S., Bešta-Gajević, R., Parić, A., & Ćavar Zeljković, S. (2021). Influence of extraction solvent on the phenolic profile and bioactivity of two achillea species. Molecules, 26(6). https://doi.org/10.3390/molecules26061601
Leyane, T. S., Jere, S. W., & Houreld, N. N. (2022). Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation. In International Journal of Molecular Sciences (Vol. 23, Issue 13). MDPI. https://doi.org/10.3390/ijms23137273
Manteu, S. H., & Nurjanah, N. T. (2018). Karakteristik rumput laut cokelat (Sargassum policystum dan Padina minor) dari perairan Pohuwato Provinsi Gorontalo. Jurnal Pengolahan Hasil Perikanan Indonesia, 21(3), 396–405.
Nawaz, H., Shad, M. A., Rehman, N., Andaleeb, H., & Ullah, N. (2020). Effect of solvent polarity on extraction yield and antioxidant properties of phytochemicals from bean (Phaseolus vulgaris) seeds. Brazilian Journal of Pharmaceutical Sciences, 56. https://doi.org/10.1590/s2175-97902019000417129
Noorjahan, A., Aiyamperumal, B., & Anantharaman, P. (2019). Characterization and Biochemical Properties of Brown Seaweed Sargassum Tenerrimum (J. agardh). International Journal of Pharmacy and Biological Sciences-IJPBS TM, 2, 9. https://doi.org/10.21276/ijpbs.2019.9.2.34
Olugbami, J. O., Gbadegesin, M. A., & Odunola, O. A. (2014). In vitro evaluation of the antioxidant potential, phenolic and flavonoid contents of the stem bark ethanol extract of Anogeissus leiocarpus HHS Public Access. In Afr J Med Med Sci (Vol. 43, Issue 1).
Palanisamy, S., Vinosha, M., Marudhupandi, T., Rajasekar, P., & Prabhu, N. M. (2017). Isolation of fucoidan from Sargassum polycystum brown algae: Structural characterization, in vitro antioxidant and anticancer activity. International Journal of Biological Macromolecules, 102, 405–412. https://doi.org/10.1016/j.ijbiomac.2017.03.182
Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: An overview. In Journal of Nutritional Science (Vol. 5). Cambridge University Press. https://doi.org/10.1017/jns.2016.41
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative Stress: Harms and Benefits for Human Health. In Oxidative Medicine and Cellular Longevity (Vol. 2017). Hindawi Limited. https://doi.org/10.1155/2017/8416763
Platzer, M., Kiese, S., Tybussek, T., Herfellner, T., Schneider, F., Schweiggert-Weisz, U., & Eisner, P. (2022). Radical Scavenging Mechanisms of Phenolic Compounds: A Quantitative Structure-Property Relationship (QSPR) Study. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.882458
Polo, L. K., & Chow, F. (2022). Variation of antioxidant capacity and antiviral activity of the brown seaweed Sargassum filipendula (Fucales, Ochrophyta) under UV radiation treatments. Applied Phycology, 3(1), 260–273.
Rohimat, R., Widowati, I., & Trianto, A. (2014). Aktivitas antioksidan ekstrak metanol rumput laut coklat (Turbinaria conoides dan sargassum cristaefolium) yang dikoleksi dari pantai rancabuaya garut jawa barat. Journal of Marine Research, 3(3), 304–313.
Salehi, B., Martorell, M., Arbiser, J. L., Sureda, A., Martins, N., Maurya, P. K., Sharifi-Rad, M., Kumar, P., & Sharifi-Rad, J. (2018). Antioxidants: Positive or negative actors? In Biomolecules (Vol. 8, Issue 4). MDPI AG. https://doi.org/10.3390/biom8040124
Sami, F. J., Soekamto, N. H., Firdaus, F., & Latip, J. (2019). Uji Aktivitas Antioksidan Ekstrak Alga Coklat Sargassum polycystum Dan Turbinaria deccurens Asal Pulau Dutungan Sulawesi Selatan Terhadap Radikal DPPH. Jurnal Kimia Riset, 4(1), 1–6.
Sanger, G., Wonggo, D., Montolalu, L., & Dotulong, V. (2022). Pigments constituents, phenolic content and antioxidant activity of brown seaweed Sargassum sp. IOP Conference Series: Earth and Environmental Science, 1033(1), 12057.
Sedjati, S., Supriyantini, E., Ridlo, A., Soenardjo, N., & Santi, V. Y. (2018). Kandungan Pigmen, Total Fenolik Dan Aktivitas Antioksidan Sargassum sp. Jurnal Kelautan Tropis, 21(2), 137. https://doi.org/10.14710/jkt.v21i2.3329
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., Prakash Mishra, A., Nigam, M., El Rayess, Y., Beyrouthy, M. El, Polito, L., Iriti, M., Martins, N., Martorell, M., Docea, A. O., … Sharifi-Rad, J. (2020). Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. In Frontiers in Physiology (Vol. 11). Frontiers Media S.A. https://doi.org/10.3389/fphys.2020.00694
Sivasankara Narayani, S., Saravanan, S., Bharathiaraja, S., & Mahendran, S. (2016). Extraction, partially purification and study on antioxidant property of fucoxanthin from Sargassum cinereum J. Agardh. Available Online Www.Jocpr.Com Journal of Chemical and Pharmaceutical Research, 8(3), 610–616. www.jocpr.com
Sobuj, M. K. A., Islam, M. A., Islam, M. S., Islam, M. M., Mahmud, Y., & Rafiquzzaman, S. M. (2021). Effect of solvents on bioactive compounds and antioxidant activity of Padina tetrastromatica and Gracilaria tenuistipitata seaweeds collected from Bangladesh. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-98461-3
Veerichetty, V., & Rafi, A. S. M. (2022). Comparative antioxidant capacity of fucoidan batches extracted from Sargassum species. AIP Conference Proceedings, 2446(1).
Yegdaneh, A., Mehdinezhad, N., Ghannadi, A., & Yegdaneh, A. (2016). Phytochemical and biological evaluation of some Sargassum species from Persian Gulf. In Research in Pharmaceutical Sciences (Vol. 11, Issue 3).
Yousefi, N., & Abbasi, S. (2022). Food proteins: Solubility & thermal stability improvement techniques. In Food Chemistry Advances (Vol. 1). Elsevier Ltd. https://doi.org/10.1016/j.focha.2022.100090
Zaidan, S., Abdillah, S., Pratami, D. K., & Utami, S. A. (2022). Nanoparticles of brown seaweed (sargassum polycystum) extract and its antioxidant activity in rats fed high-fat diet. Int J App Pharm, 14(4), 186–191.
Baek, S. H., Cao, L., Jeong, S. J., Kim, H. R., Nam, T. J., & Lee, S. G. (2021). The Comparison of Total Phenolics, Total Antioxidant, and Anti-Tyrosinase Activities of Korean Sargassum Species. Journal of Food Quality, 2021. https://doi.org/10.1155/2021/6640789
Balasubramaniam, V., June Chelyn, L., Vimala, S., Mohd Fairulnizal, M. N., Brownlee, I. A., & Amin, I. (2020). Carotenoid composition and antioxidant potential of Eucheuma denticulatum, Sargassum polycystum and Caulerpa lentillifera. Heliyon, 6(8). https://doi.org/10.1016/j.heliyon.2020.e04654
Catarino, M. D., Silva-Reis, R., Chouh, A., Silva, S., Braga, S. S., Silva, A. M. S., & Cardoso, S. M. (2023). Applications of Antioxidant Secondary Metabolites of Sargassum spp. Marine Drugs, 21(3), 172.
de Menezes, B. B., Frescura, L. M., Duarte, R., Villetti, M. A., & da Rosa, M. B. (2021). A critical examination of the DPPH method: Mistakes and inconsistencies in stoichiometry and IC50 determination by UV–Vis spectroscopy. Analytica Chimica Acta, 1157. https://doi.org/10.1016/j.aca.2021.338398
Edison, E., Diharmi, A., Ariani, N. M., & Ilza, M. (2020). Komponen bioaktif dan aktivitas antioksidan ekstrak kasar Sargassum plagyophyllum. Jurnal Pengolahan Hasil Perikanan Indonesia, 23(1), 58–66.
Firdaus, M. (2013). Antioxidant Activity Index of Brown Seaweed (Sargassum aquifolium) Extract. Indonesian Journal of Fishery Product Processing, 16(1), 42–47.
Gazali, M., Zamani, N., Nurjanah, N., Zulfadhli, Z., & Safutra, E. (2018). Eksplorasi potensi senyawa bioaktif makroalga laut Sargassum sp asal Pesisir Aceh Barat sebagai agen antioksidan. Journal of Aceh Aquatic Sciences, 1(1).
Jimenez-Lopez, C., Pereira, A. G., Lourenço-Lopes, C., Garcia-Oliveira, P., Cassani, L., Fraga-Corral, M., Prieto, M. A., & Simal-Gandara, J. (2021). Main bioactive phenolic compounds in marine algae and their mechanisms of action supporting potential health benefits. Food Chemistry, 341. https://doi.org/10.1016/j.foodchem.2020.128262
Kaczorová, D., Karalija, E., Dahija, S., Bešta-Gajević, R., Parić, A., & Ćavar Zeljković, S. (2021). Influence of extraction solvent on the phenolic profile and bioactivity of two achillea species. Molecules, 26(6). https://doi.org/10.3390/molecules26061601
Leyane, T. S., Jere, S. W., & Houreld, N. N. (2022). Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation. In International Journal of Molecular Sciences (Vol. 23, Issue 13). MDPI. https://doi.org/10.3390/ijms23137273
Manteu, S. H., & Nurjanah, N. T. (2018). Karakteristik rumput laut cokelat (Sargassum policystum dan Padina minor) dari perairan Pohuwato Provinsi Gorontalo. Jurnal Pengolahan Hasil Perikanan Indonesia, 21(3), 396–405.
Nawaz, H., Shad, M. A., Rehman, N., Andaleeb, H., & Ullah, N. (2020). Effect of solvent polarity on extraction yield and antioxidant properties of phytochemicals from bean (Phaseolus vulgaris) seeds. Brazilian Journal of Pharmaceutical Sciences, 56. https://doi.org/10.1590/s2175-97902019000417129
Noorjahan, A., Aiyamperumal, B., & Anantharaman, P. (2019). Characterization and Biochemical Properties of Brown Seaweed Sargassum Tenerrimum (J. agardh). International Journal of Pharmacy and Biological Sciences-IJPBS TM, 2, 9. https://doi.org/10.21276/ijpbs.2019.9.2.34
Olugbami, J. O., Gbadegesin, M. A., & Odunola, O. A. (2014). In vitro evaluation of the antioxidant potential, phenolic and flavonoid contents of the stem bark ethanol extract of Anogeissus leiocarpus HHS Public Access. In Afr J Med Med Sci (Vol. 43, Issue 1).
Palanisamy, S., Vinosha, M., Marudhupandi, T., Rajasekar, P., & Prabhu, N. M. (2017). Isolation of fucoidan from Sargassum polycystum brown algae: Structural characterization, in vitro antioxidant and anticancer activity. International Journal of Biological Macromolecules, 102, 405–412. https://doi.org/10.1016/j.ijbiomac.2017.03.182
Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: An overview. In Journal of Nutritional Science (Vol. 5). Cambridge University Press. https://doi.org/10.1017/jns.2016.41
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative Stress: Harms and Benefits for Human Health. In Oxidative Medicine and Cellular Longevity (Vol. 2017). Hindawi Limited. https://doi.org/10.1155/2017/8416763
Platzer, M., Kiese, S., Tybussek, T., Herfellner, T., Schneider, F., Schweiggert-Weisz, U., & Eisner, P. (2022). Radical Scavenging Mechanisms of Phenolic Compounds: A Quantitative Structure-Property Relationship (QSPR) Study. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.882458
Polo, L. K., & Chow, F. (2022). Variation of antioxidant capacity and antiviral activity of the brown seaweed Sargassum filipendula (Fucales, Ochrophyta) under UV radiation treatments. Applied Phycology, 3(1), 260–273.
Rohimat, R., Widowati, I., & Trianto, A. (2014). Aktivitas antioksidan ekstrak metanol rumput laut coklat (Turbinaria conoides dan sargassum cristaefolium) yang dikoleksi dari pantai rancabuaya garut jawa barat. Journal of Marine Research, 3(3), 304–313.
Salehi, B., Martorell, M., Arbiser, J. L., Sureda, A., Martins, N., Maurya, P. K., Sharifi-Rad, M., Kumar, P., & Sharifi-Rad, J. (2018). Antioxidants: Positive or negative actors? In Biomolecules (Vol. 8, Issue 4). MDPI AG. https://doi.org/10.3390/biom8040124
Sami, F. J., Soekamto, N. H., Firdaus, F., & Latip, J. (2019). Uji Aktivitas Antioksidan Ekstrak Alga Coklat Sargassum polycystum Dan Turbinaria deccurens Asal Pulau Dutungan Sulawesi Selatan Terhadap Radikal DPPH. Jurnal Kimia Riset, 4(1), 1–6.
Sanger, G., Wonggo, D., Montolalu, L., & Dotulong, V. (2022). Pigments constituents, phenolic content and antioxidant activity of brown seaweed Sargassum sp. IOP Conference Series: Earth and Environmental Science, 1033(1), 12057.
Sedjati, S., Supriyantini, E., Ridlo, A., Soenardjo, N., & Santi, V. Y. (2018). Kandungan Pigmen, Total Fenolik Dan Aktivitas Antioksidan Sargassum sp. Jurnal Kelautan Tropis, 21(2), 137. https://doi.org/10.14710/jkt.v21i2.3329
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., Prakash Mishra, A., Nigam, M., El Rayess, Y., Beyrouthy, M. El, Polito, L., Iriti, M., Martins, N., Martorell, M., Docea, A. O., … Sharifi-Rad, J. (2020). Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. In Frontiers in Physiology (Vol. 11). Frontiers Media S.A. https://doi.org/10.3389/fphys.2020.00694
Sivasankara Narayani, S., Saravanan, S., Bharathiaraja, S., & Mahendran, S. (2016). Extraction, partially purification and study on antioxidant property of fucoxanthin from Sargassum cinereum J. Agardh. Available Online Www.Jocpr.Com Journal of Chemical and Pharmaceutical Research, 8(3), 610–616. www.jocpr.com
Sobuj, M. K. A., Islam, M. A., Islam, M. S., Islam, M. M., Mahmud, Y., & Rafiquzzaman, S. M. (2021). Effect of solvents on bioactive compounds and antioxidant activity of Padina tetrastromatica and Gracilaria tenuistipitata seaweeds collected from Bangladesh. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-98461-3
Veerichetty, V., & Rafi, A. S. M. (2022). Comparative antioxidant capacity of fucoidan batches extracted from Sargassum species. AIP Conference Proceedings, 2446(1).
Yegdaneh, A., Mehdinezhad, N., Ghannadi, A., & Yegdaneh, A. (2016). Phytochemical and biological evaluation of some Sargassum species from Persian Gulf. In Research in Pharmaceutical Sciences (Vol. 11, Issue 3).
Yousefi, N., & Abbasi, S. (2022). Food proteins: Solubility & thermal stability improvement techniques. In Food Chemistry Advances (Vol. 1). Elsevier Ltd. https://doi.org/10.1016/j.focha.2022.100090
Zaidan, S., Abdillah, S., Pratami, D. K., & Utami, S. A. (2022). Nanoparticles of brown seaweed (sargassum polycystum) extract and its antioxidant activity in rats fed high-fat diet. Int J App Pharm, 14(4), 186–191.