Evaluation of leukocyturia among suspected urinary tract infection patients
DOI:
https://doi.org/10.35335/midwifery.v13i5.2137Keywords:
Diabetes Mellitus, Hematuria, Leukocyturia, Primary Healthcare, Urinary Tract InfectionAbstract
Urinary tract infections (UTIs) remain a major global health concern and frequently present in primary care, yet epidemiological data on urinalysis markersâ€â€Âparticularly leukocyturia and hematuriaâ€â€Âare limited in community-based clinics. This gap reduces diagnostic accuracy because most existing evidence originates from hospital settings. This study aimed to determine the prevalence and characteristics of leukocyturia among suspected UTI patients and to analyze its association with hematuria in a community outpatient clinic. A retrospective cross-sectional study was conducted using medical records from the Ibnu Sina Clinic, Balikpapan, Indonesia, from January to June 2025. All patients meeting the inclusion criteria were analyzed using descriptive statistics and comparative tests in SPSS version 25. Among 87 eligible patients, most were elderly women, with high urine specific gravity and normal urinary pH. Leukocyturia was predominantly mild-to-moderate (6–20 leukocytes/HPF), and diabetes mellitus emerged as the most frequent comorbidity. A significant association was found between leukocyturia and hematuria (p < 0.05), indicating that increasing inflammatory burden corresponds with greater red blood cell presence in urine. In conclusion, leukocyturia prevalence was highest among elderly diabetic women in this community-based setting. Routine urinalysis remains essential for early infection detection where urine culture is not readily accessible. Future research should incorporate urine culture and antimicrobial resistance testing to enhance diagnostic precision.
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Aldy, M., Rossi, L., & De Luca, F. (2022). Epidemiological insights into urinary tract infections: sex-based prevalence and clinical implications. Journal of Infection. https://doi.org/10.1016/j.jinf.2022.05.007
Aman, A. T., Nuryastuti, T., Aman, A. H., & Linda, V. A. N. (2022). The profile of bacteria isolated from urine culture of adults with urinary tract infection in Yogyakarta 2007–2022. Indonesian Journal of Biomedical and Clinical Sciences. https://doi.org/10.22146/inajbcs.v56i3.15890
Arbianti, N., Prihatiningsih, S., Indriani, D. W., & Indriati, D. W. (2020). A study of urinary tract infections and prevalence of antibiotic resistant pathogens in patients with diabetes mellitus from a public hospital in Surabaya, Indonesia. Germs. https://pmc.ncbi.nlm.nih.gov/articles/PMC7572203/
Baier, E., Kluge, I. A., Hakroush, S., Tampe, D., & Tampe, B. (2023). Leukocyturia and hematuria enable non-invasive differentiation of Bowman’s capsule rupture severity in PR3-ANCA glomerulonephritis. Journal of Nephrology, 36(3), 799–808. https://doi.org/10.1007/s40620-023-01579-0
Bari’ah, P. A., Amelin, F., & Putra, A. E. (2025). Profil klinis dan bakteriologis infeksi saluran kemih pada anak di RSUP Dr. M. Djamil Padang tahun 2017–2021. Sinergi. https://doi.org/10.62335/sinergi.v2i5.1214
Flores-Mireles, A. L., Walker, J. N., Caparon, M., & Hultgren, S. J. (2015). Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nature Reviews Microbiology, 13(5), 269–284. https://doi.org/10.1038/nrmicro3432
González, M. J., Robino, L., Zunino, P., & Scavone, P. (2024). Urinary tract infection: is it time for a new approach considering a gender perspective and new microbial advances? Frontiers in Urology, 4, 1487858. https://doi.org/10.3389/fruro.2024.1487858
Gupta, K., Hooton, T. M., Naber, K. G., Wullt, B., Colgan, R., Miller, L. G., Moran, G. J., Nicolle, L. E., Raz, R., Schaeffer, A. J., & Soper, D. E. (2011). International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clinical Infectious Diseases, 52(5), e103--e120. https://doi.org/10.1093/cid/ciq257
Hickling, D. R., Sun, T. T., & Wu, X. R. (2017). Anatomy and physiology of the urinary tract: relation to host defense and microbial infection. In Urinary Tract Infections: Molecular Pathogenesis and Clinical Management (pp. 1–25). ASM Press.
Imanda, R. (2019). Relationship between education level and personal hygiene behavior among adults in Indonesia. Indonesian Journal of Public Health Studies. https://scholar.google.com/scholar?cluster=175391885
Javier, R. M., Rahmat, A. S., & Noerraihana, H. L. (2023). Prevalence and contributing factors of urinary tract infection in HIV patients: A systematic review. Pan Asian Journal of Medicine. https://doi.org/10.5005/jp-journals-10081-1410
Joshi, D. D., Survase, C. K., & Ballaiya, R. (2022). Assessment of the urinary tract infection prevalence in febrile subjects of age less than 5 years: a prospective clinical study. Health Research Clinical Archives. https://go.gale.com/ps/i.do?id=GALE%7CA765922687
Karima, E. B., Samira, M., Noura, A. S., Noura, L., & Sanae, S. (2022). Increased morbidity of children with sickle cell disease facing bacterial contamination of water in some areas of the Province of Kenitra (Morocco). International Journal of Health Sciences, 12728–12744. https://doi.org/10.53730/ijhs.v6nS2.8349
Khairunnisa, N. (2013). Hubungan tingkat konsumsi air putih dengan status hidrasi pada mahasiswa UIN Syarif Hidayatullah Jakarta. https://repository.uinjkt.ac.id/dspace/handle/123456789/42644
Khoirul, A. (2017). Hubungan usia dan leukocyturia pada pasien infeksi saluran kemih di rumah sakit pemerintah. Jurnal Kesehatan Indonesia. https://scholar.google.com/scholar?cluster=671582023
Kocur, S. B., Noppenberg, M., & Sowińska, I. (2023). Selected risk factors for urinary tract infections. Przegląd Pielęgniarski. https://doi.org/10.5114/ppiel.2023.133337
Lee, J. H., & Kim, M. J. (2024). Hematuria and leukocyturia correlation as diagnostic markers for UTI in female patients. Journal of Clinical Laboratory Analysis, 38(4), e24983. https://doi.org/10.1002/jcla.24983
Medina, M., & Castillo-Pino, E. (2019). An introduction to the epidemiology and burden of urinary tract infections. Therapeutic Advances in Urology, 11, 1756287219832172. https://doi.org/10.1177/1756287219832172
Monik, R. (2020). Hubungan kadar gula darah dengan kejadian infeksi saluran kemih pada pasien diabetes mellitus. https://repository.uir.ac.id/18120/
Nassaji, M., & Ghorbani, R. (2019). Association Between Obesity and Urinary Tract Infection: A Case–Control Study. BioMed Research International. https://doi.org/10.1155/2019/6752854
Nataprawira, H. M., & Pratama, A. A. (2019). Complicated urinary tract tuberculosis in a 13-year-old adolescent with chronic kidney disease. Case Reports in Nephrology. https://doi.org/10.1155/2019/7370150
Nicolle, L. E. (2019). Asymptomatic bacteriuria: when to screen and when to treat. Infectious Disease Clinics of North America, 33(3), 413–426. https://doi.org/10.1016/j.idc.2019.04.002
Pallet, A., & Hand, K. (2018). Antibiotic stewardship: managing cephalosporin resistance in urinary tract infections. BMJ. https://doi.org/10.1136/bmj.k2820
Ramdani, D., Hasmono, D., & Islam, S. (2015). Ciprofloxacin is effective in benign prostatic hyperplasia patients with urethral catheters. Proceedings of FMIPA Conference. https://www.academia.edu/download/78465220/download-fullpapers-fmi0cb36225abfull.pdf
Skrajnowska, D., & Bobrowska-Korczak, B. (2024). The Effects of Diet, Dietary Supplements, Drugs and Exercise on Physical, Diagnostic Values of Urine Characteristics. Nutrients. https://www.mdpi.com/2072-6643/16/18/3141
Sunjaya, J., Bororing, S. R., & Iryaningrum, M. R. (2021). The association between urine leukocytes and types of urinary tract infection. Jurnal Urologi Indonesia. https://doi.org/10.32421/juri.v29i1.746
Sunjaya, J., Bororing, S. R., & Iryaningrum, M. R. A. (2022). A Systematic Review: The Association Between Urine Leukocytes and the Types of Urinary Tract Infection. Indonesian Journal of Urology.
Venuti, K., Cabrera, C., Burkett, L. S., & Bradley, M. S. (2021). Impact of menopausal status on uropathogen prevalence and antimicrobial resistance profiles. Urogynecology, 27(1), e13--e17.
Wirastiti, N. M. A., Nilawati, G. A. P., & Suarta, I. K. (2021). Characteristic and bacterial sensitivity of pediatric patients with urinary tract infection in Sanglah hospital. Medicina Udayana. https://medicinaudayana.ejournals.ca/index.php/medicina/article/view/667
Yale Medicine. (2024). Female has a short urethra … bacteria don’t have as far to travel to reach the bladder.
Zaetun, S., Gede, L. S., Agrijanti, M., & Anulus, A. (2017). Sensitivity test and specificity invention gram negative rods with gram staining for screening test of urinary tract infection. https://www.academia.edu/download/98002644/2358.pdf
Zaetun, S., & Srigede, L. (2025). Blood urine positivity rate dipstick method on the incidence of anemia in urinary tract infection patients. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC12102672/


