Lipid-based nanoparticle delivery system approach for diabetic wounds: A review
DOI:
https://doi.org/10.35335/midwifery.v13i5.2148Keywords:
Bioavailability, Diabetic Wounds, Drug Delivery System, Lipid Nanoparticles, TransdermalAbstract
Diabetic wounds are a chronic complication that is difficult to heal due to impaired blood circulation, oxidative stress, and microbial infection. Conventional therapies are often ineffective due to poor drug penetration into damaged skin tissue and limited bioavailability of active compounds. Lipid nanoparticle-based drug delivery technology was developed to overcome these obstacles by increasing stability, skin penetration ability, and controlled drug release. Objective: This article aims to comprehensively review the role of lipid-based nanoparticle delivery systems in improving the effectiveness of diabetic wound healing therapy, including the mechanisms of absorption enhancement, active substance stability, and pharmacological activity. Methods: This study is a systematic literature review of national and international publications over the past ten years (2015–2025). Data sources were obtained from PubMed, ScienceDirect, and Google Scholar databases using keywords “lipid nanoparticles,†“diabetic wound healing,†and “transdermal drug delivery.†Inclusion criteria included experimental studies and review articles discussing lipid nanoparticle formulations and their therapeutic effects on diabetic wounds. Results: Various studies have shown that lipid-based nanoparticle systems, including nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs), can improve the stability and permeation of active ingredients such as curcumin, asiatic acid, and other herbal extracts through the skin. This improvement contributes to better anti-inflammatory, antioxidant, and antibacterial activities, thereby accelerating the healing process of diabetic wounds. Conclusion: Lipid-based nanoparticle technology offers an innovative approach to diabetic wound therapy by improving the stability, bioavailability, and effectiveness of active ingredients. Further development is needed for formulation optimization and clinical validation to ensure the safety and effectiveness of its use in diabetic patients.
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References
Akanda M, Mithu MSH, Douroumis D. Solid lipid nanoparticles: An effective lipid-based technology for cancer treatment. J Drug Deliv Sci Technol. 2023;86:104709.
Akkus G, Sert M. Diabetic foot ulcers: A devastating complication of diabetes mellitus continues non-stop in spite of new medical treatment modalities. World J Diabetes. 2022;13(12):1106.
Akombaetwa N, Ilangala AB, Thom L, Memvanga PB, Witika BA, Buya AB. Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications. Pharmaceutics. 2023;15(2):1–47.
Alkilani AZ, Nasereddin J, Hamed R, Nimrawi S, Hussein G, Abo-Zour H, et al. Beneath the skin: a review of current trends and future prospects of transdermal drug delivery systems. Pharmaceutics. 2022;14(6):1152.
Araújo G de MS, Loureiro AIS, Rodrigues JL, Barros PAB, Halicki PCB, Ramos DF, et al. Toward a platform for the treatment of burns: An assessment of nanoemulsions vs. nanostructured lipid carriers loaded with curcumin. Biomedicines. 2023;11(12):3348.
Ashfaq R, Rasul A, Asghar S, Kovács A, Berkó S, Budai-Szűcs M. Lipid nanoparticles: an effective tool to improve the bioavailability of nutraceuticals. Int J Mol Sci. 2023;24(21):15764.
Baloch J, Sohail MF, Sarwar HS, Kiani MH, Khan GM, Jahan S, et al. Self-nanoemulsifying drug delivery system (SNEDDS) for improved oral bioavailability of chlorpromazine: in vitro and in vivo evaluation. Medicina (B Aires). 2019;55(5):210.
Bamisaye A, Adekola MA, Abati SM, Etafo NO, Ademola OS, Joseph PT, et al. Recent advances in metal/metal-oxide nanoparticle-polymer nanohybrid for biomedical applications. Mater Today Chem. 2025;49:103086.
Buya AB, Beloqui A, Memvanga PB, Préat V. Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery. Pharmaceutics. 2020;12(12):1194.
Cedillo-Cortezano M, Martinez-Cuevas LR, López JAM, Barrera López IL, Escutia-Perez S, Petricevich VL. Use of medicinal plants in the process of wound healing: a literature review. Pharmaceuticals. 2024;17(3):303.
Chatzidaki MD, Mitsou E. Advancements in nanoemulsion-based drug delivery across different administration routes. Pharmaceutics. 2025;17(3):337.
Chauhan I, Yasir M, Verma M, Singh AP. Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery. J Cardiovasc Thorac Res. 2020;10(2):150–65.
Chelliah R, Rubab M, Vijayalakshmi S, Karuvelan M, Barathikannan K, Oh DH. Liposomes for drug delivery: Classification, therapeutic applications, and limitations. Next Nanotechnol. 2025;8:100209.
Costa R, Nunes C, Lima SAC, Gameiro P, Reis S. Nanostructured lipid carrier-embedded hydrogels for enhanced skin delivery of quercetin: Optimized formulation with pomegranate oil for UVB protection. Int J Pharm. 2025;125894.
Dasari N, Jiang A, Skochdopole A, Chung J, Reece EM, Vorstenbosch J, et al. Updates in diabetic wound healing, inflammation, and scarring. In: Seminars in plastic surgery. Thieme Medical Publishers, Inc.; 2021. p. 153–8.
Ezhilarasu H, Vishalli D, Dheen ST, Bay BH, Srinivasan DK. Nanoparticle-based therapeutic approach for diabetic wound healing. Nanomaterials. 2020;10(6):1234.
Farooq S, Habib M, Cardozo O, Ullah K, Pandey AK, Said Z. Exploring the impact of particle stability, size, and morphology on nanofluid thermal conductivity: a comprehensive review for energy applications. Adv Colloid Interface Sci. 2025;103495.
Gajbhiye KR, Salve R, Narwade M, Sheikh A, Kesharwani P, Gajbhiye V. Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics. Mol Cancer. 2023;22(1):160.
Hassan AAA, Ramadan E, Kristó K, Regdon Jr G, Sovány T. Lipid-Polymer Hybrid Nanoparticles as a Smart Drug Delivery System for Peptide/Protein Delivery. Pharmaceutics. 2025;17(6):797.
Hein ZM, Gopalakrishna PK, Kanuri AK, Thomas W, Hussan F, Naik VR, et al. Centella asiatica: Advances in Extraction Technologies, Phytochemistry, and Therapeutic Applications. Life. 2025;15(7):1081.
Hmingthansanga V, Singh N, Banerjee S, Manickam S, Velayutham R, Natesan S. Improved topical drug delivery: Role of permeation enhancers and advanced approaches. Pharmaceutics. 2022;14(12):2818.
Ijjeh Y, Alsarayreh N, Rifai A, Abdelnabi H, Al-Mahamid S, Alqudah DA, et al. Quality by digital design for accelerated sustainable nanomedicine development. Eur J Pharm Sci. 2025;107239.
Jacob S, Rao R, Gorain B, Boddu SHS, Nair AB. Solid lipid nanoparticles and nanostructured lipid carriers for anticancer phytochemical delivery: Advances, challenges, and future prospects. Pharmaceutics. 2025;17(8):1079.
Jafar G, Putriyanti A fira, Muhsinin S, Kencana B. Formulation and Characterization of Tretinoin Nanostructured Lipid Carriers Using Apifil and Cremophore. 2025;5(3):477–84.
Jafar G, Salsabilla S, Santoso R. Original Article DEVELOPMENT AND CHARACTERIZATION OF COMPRITOL ATO ® BASE IN NANOSTRUCTURED LIPID CARRIERS FORMULATION WITH THE PROBE SONICATION METHOD. 2022;14(4):64–6.
Jafar G, Sucipto YK, Supriadi D. Development of the Formula and Characterization of Tretinoin Nanostructured Lipid Carriers ( NLC ) With Precirol ® Ato5 Using the Sonicator Probe Method. 2024;10(6):62–7.
Kolimi P, Narala S, Nyavanandi D, Youssef AAA, Dudhipala N. Innovative treatment strategies to accelerate wound healing: trajectory and recent advancements. Cells. 2022;11(15):2439.
Kubatka P, Mazurakova A, Samec M, Koklesova L, Zhai K, Al-Ishaq R, et al. Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progressionâ€â€Â3PM pathways. Epma J. 2021;12(4):559–87.
Kumar A, Kanwar R, Mehta SK. Nanoemulsion as an effective delivery vehicle for essential oils: properties, formulation methods, destabilizing mechanisms and applications in agri-food sector. Next Nanotechnol. 2025;7:100096.
Kumari A, Raina N, Wahi A, Goh KW, Sharma P, Nagpal R, et al. Wound-healing effects of curcumin and its nanoformulations: a comprehensive review. Pharmaceutics. 2022;14(11):2288.
Liu L, Zhao W, Ma Q, Gao Y, Wang W, Zhang X, et al. Functional nano-systems for transdermal drug delivery and skin therapy. Nanoscale Adv. 2023;5(6):1527–58.
Liu P, Chen G, Zhang J. A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives. Molecules. 2022;27(4):1372.
Lok KH, Loo HL, Chuah LH. Topical and transdermal lipid-polymer hybrid nanoparticles (LPN): an integration in advancing dermatological treatments. Drug Deliv Transl Res. 2025;1–37.
Lombardo D, Kiselev MA. Methods of liposomes preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine application. Pharmaceutics. 2022;14(3):543.
López KL, Ravasio A, González-Aramundiz JV, Zacconi FC. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) prepared by microwave and ultrasound-assisted synthesis: promising green strategies for the nanoworld. Pharmaceutics. 2023;15(5):1333.
Luo Y, Liu C, Li C, Jin M, Pi L, Jin Z. The incidence of lower extremity amputation and its associated risk factors in patients with diabetic foot ulcers: A metaâ€ÂÂanalysis. Int Wound J. 2024;21(7):e14931.
Mall J, Naseem N, Haider MF, Rahman MA, Khan S, Siddiqui SN. Nanostructured lipid carriers as a drug delivery system: A comprehensive review with therapeutic applications. Intell Pharm. 2024;
Mehta M, Bui TA, Yang X, Aksoy Y, Goldys EM, Deng W. Lipid-based nanoparticles for drug/gene delivery: an overview of the production techniques and difficulties encountered in their industrial development. ACS Mater Au. 2023;3(6):600–19.
Mieczkowski M, Mrozikiewicz-Rakowska B, Kowara M, Kleibert M, Czupryniak L. The problem of wound healing in diabetesâ€â€Âfrom molecular pathways to the design of an animal model. Int J Mol Sci. 2022;23(14):7930.
Mukherjee A, Waters AK, Kalyan P, Achrol AS, Kesari S, Yenugonda VM. Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives. Int J Nanomedicine. 2019;1937–52.
Mushtaq A, Wani SM, Malik AR, Gull A, Ramniwas S, Nayik GA, et al. Recent insights into Nanoemulsions: Their preparation, properties and applications. Food Chem X. 2023;18:100684.
Negut I, Bita B. Polymeric micellar systemsâ€â€Âa special emphasis on “smart†drug delivery. Pharmaceutics. 2023;15(3):976.
Van Norman GA. Limitations of animal studies for predicting toxicity in clinical trials: is it time to rethink our current approach? JACC Basic to Transl Sci. 2019;4(7):845–54.
Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W. Liposomes: structure, composition, types, and clinical applications. Heliyon. 2022;8(5).
Pandey S, Shaikh F, Gupta A, Tripathi P, Yadav JS. A recent update: solid lipid nanoparticles for effective drug delivery. Adv Pharm Bull. 2021;12(1):17.
Rahman F, Hendradi E, Purwanti T. Lipids selection and methods of nanostructured lipid carrier for topical use. Int J Drug Deliv Technol. 2024;14(3):1880–9.
Ramadon D, McCrudden MTC, Courtenay AJ, Donnelly RF. Enhancement strategies for transdermal drug delivery systems: Current trends and applications. Drug Deliv Transl Res. 2022;12(4):758–91.
Saghazadeh S, Rinoldi C, Schot M, Kashaf SS, Sharifi F, Jalilian E, et al. Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev. 2018;127:138–66.
Septianti RD, Jafar G, Dinayanti WN, Dinata DI. Formulation and characterization of bay leaf extract nanophytosomes (Syzgium polyanthum) and affinity study of interaction with alpha glucosidase enzyme as antidiabetic. Sci Midwifery. 2025;13(1):178–87.
Sun D, Chang Q, Lu F. Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels. J Tissue Eng. 2024;15:20417314241265200.
Viegas C, PatrÃÂÂcio AB, Prata JM, Nadhman A, Chintamaneni PK, Fonte P. Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review. Pharmaceutics. 2023;15(6):1593.
Wang T, Yu T, Liu Q, Sung TC, Higuchi A. Lipid nanoparticle technology-mediated therapeutic gene manipulation in the eyes. Mol Ther Nucleic Acids. 2024;35(3).
Yadav P, Singh M, Vinayagam R, Shukla P. Therapies and Delivery Systems for Diabetic Wound Care: Current Insights and Future Pathways. Front Pharmacol. 2025;16:1628252.
Yan L, Wang Y, Feng J, Ni Y, Zhang T, Cao Y, et al. Mechanism and application of fibrous proteins in diabetic wound healing: A literature review. Front Endocrinol (Lausanne). 2024;15:1430543.
Yan Y, Sun Y, Li Y, Wang Z, Xue L, Wang F. Advancing cancer therapy: Nanomaterial-based encapsulation strategies for enhanced delivery and efficacy of curcumin. Mater Today Bio. 2025;101963.
Zaid Alkilani A, McCrudden MTC, Donnelly RF. Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015;7(4):438–70.
