Article review: The role of probiotics in maintaining balance intestinal microbiota on diarrhea infection therapy
DOI:
https://doi.org/10.35335/midwifery.v13i5.2165Keywords:
Diarrhea Infection, Gut Microbiota, Microbiota Balance, ProbioticsAbstract
Diarrhea infections are a significant global health problem, especially in developing countries and can be caused by bacterial, viral or parasitic infections. Antibiotics are often given times ineffective in long-term use and risk disrupting the balance of intestinal microbiota. So that probiotics are needed that come from living microorganisms that provide health benefits if consumed in sufficient quantities. Review This article aims to review the role of probiotics in maintaining the balance of intestinal microbiota and their effectiveness in diarrheal infection therapy. Through literature analysis, several probiotic strains such as Lactobacillus and Bifidobacterium have shown their ability to inhibit the growth of pathogens, such as Escherichia coli and Clostridium difficile, through nutrient competition, production of antimicrobial substances, and immune modulation. This article concludes that probiotics have great potential as an additional therapy that is safe, effective and has minimal side effects in treating diarrheal infections. However, further studies are needed to determine the optimal dose, duration of use, and effectiveness of probiotics in various populations and types of diarrhea.
Downloads
References
Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., … Rusu, A. V. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Frontiers in Microbiology, 13, 999001.
Alou, M. T., Lagier, J.-C., & Raoult, D. (2016). Diet influence on the gut microbiota and dysbiosis related to nutritional disorders. Human Microbiome Journal, 1, 3–11.
Azagra-Boronat, I., Massot-Cladera, M., Knipping, K., Garssen, J., Ben Amor, K., Knol, J., … Pérez-Cano, F. J. (2020). Strain-specific probiotic properties of bifidobacteria and lactobacilli for the prevention of diarrhea caused by rotavirus in a preclinical model. Nutrients, 12(2), 498.
Cameron, D., Hock, Q. S., Kadim, M., Mohan, N., Ryoo, E., Sandhu, B., … Guarino, A. (2017). Probiotics for gastrointestinal disorders: proposed recommendations for children of the Asia-Pacific region. World Journal of Gastroenterology, 23(45), 7952.
Dey, P., Mukherjee, S. K., & Parai, D. (2023). Association of Probiotics and Prebiotics with Human Microbiome and the Functioning of Immune System. In Probiotics, Prebiotics, Synbiotics, and Postbiotics: Human Microbiome and Human Health (pp. 101–115). Springer.
Dong, H., Liu, B., Li, A., Iqbal, M., Mehmood, K., Jamil, T., … Wu, Q. (2021). Microbiome analysis reveals the attenuation effect of lactobacillus from yaks on diarrhea via modulation of gut microbiota. Frontiers in Cellular and Infection Microbiology, 10, 610781.
Fadillah, A. (n.d.). PENGARUH PEMBERIAN VITAMIN D3 TERHADAP EKSPRESI TNF-α DAN TGF-β SERTA PERBAIKAN MUKOSA KOLON PADA MENCIT MODEL KOLITIS.
Gallo, A., Passaro, G., Gasbarrini, A., Landolfi, R., & Montalto, M. (2016). Modulation of microbiota as treatment for intestinal inflammatory disorders: an uptodate. World Journal of Gastroenterology, 22(32), 7186.
Goldenberg, J. Z., Yap, C., Lytvyn, L., Lo, C. K., Beardsley, J., Mertz, D., & Johnston, B. C. (2017). Probiotics for the prevention of Clostridium difficileâ€ÂÂassociated diarrhea in adults and children. Cochrane Database of Systematic Reviews, (12).
Gul, S., & Durante-Mangoni, E. (2024). Unraveling the puzzle: health benefits of probioticsâ€â€Âa comprehensive review. Journal of Clinical Medicine, 13(5), 1436.
Gupta, V. K., Paul, S., & Dutta, C. (2017). Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity. Frontiers in Microbiology, 8, 1162.
Hill, C., Guarner, F., Reid, G., Gibson, G. R., Merenstein, D. J., Pot, B., … Salminen, S. (2014). Activity of cecropin P1 and FA-LL-37 against urogenital microflora. Nature Reviews Gastroenterology and Hepatology, 11(8), 506.
Iancu, M. A., Profir, M., RoÅŸu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023). Revisiting the intestinal microbiome and its role in diarrhea and constipation. Microorganisms, 11(9), 2177.
Jiang, Y., Ye, L., Cui, Y., Yang, G., Yang, W., Wang, J., … Huang, H. (2017). Effects of Lactobacillus rhamnosus GG on the maturation and differentiation of dendritic cells in rotavirus-infected mice. Beneficial Microbes, 8(4), 645–656.
Kim, C. H. (2021). Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids. Cellular & Molecular Immunology, 18(5), 1161–1171.
Li, Y., Xia, S., Jiang, X., Feng, C., Gong, S., Ma, J., … Yin, Y. (2021). Gut microbiota and diarrhea: an updated review. Frontiers in Cellular and Infection Microbiology, 11, 625210.
Mahajan, P., Kulkarni, A., Bandre, A., Subramanian, S., & Mahajan, S. (2021). Role of gut microbiota in autoimmune diseases: a review. J Vaccines Immunol, 6(163), 1–14.
Puteri, A. D., Syahfitri, C. A., Isnaeni, L. M. A., & Yusristin, D. (n.d.). Faktor-Faktor Penyebab Kejadian Diare Pada Balita Di Wilayah Kerja Puskesmas Air Tiris.
Raheem, A., Liang, L., Zhang, G., & Cui, S. (2021). Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation. Frontiers in Immunology, 12, 616713.
Rigo-Adrover, M. D. M., Van Limpt, K., Knipping, K., Garssen, J., Knol, J., Costabile, A., … Pérez-Cano, F. J. (2018). Preventive effect of a synbiotic combination of galacto-and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections. Frontiers in Immunology, 9, 1318.
Sánchez, B., Delgado, S., Blancoâ€ÂÂMÃÂÂguez, A., Lourenço, A., Gueimonde, M., & Margolles, A. (2017). Probiotics, gut microbiota, and their influence on host health and disease. Molecular Nutrition & Food Research, 61(1), 1600240.
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014). The role of short-chain fatty acids in health and disease. Advances in Immunology, 121, 91–119.
Ulfah, M. M., & Kusumawati, N. R. D. (2022). Pengaruh Pemberian Probiotik Terhadap Integritas Usus pada Obesitas: Uji Coba pada Tikus Sprague Dawley. Sari Pediatri, 24(3), 157–164.
Vogt, S. L., & Finlay, B. B. (2017). Gut microbiota-mediated protection against diarrheal infections. Journal of Travel Medicine, 24(suppl_1), S39–S43.
Wulandari, P., & Permadani, A. A. (2024). Pengaruh Sanitasi Dasar dan Sosial Ekonomi Terhadap Penyakit Diare pada Balita di Wilayah Kerja Puskesmas Sukabumi. BALABA, 20(2), 65–73.
