Serum 25-hydroxy vitamin d deficiency against IL 17 acne vulgaris
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Feb 28, 2023
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Abstract
Vitamin D is essential to immune system function and influences many dermatological diseases, such as psoriasis and atopic dermatitis, a fat-soluble steroid hormone derivative sourced from food intake and synthesized in the skin through exposure to sunlight. Vitamin D deficiency is recognized as a global problem, with high cases in South and Southeast Asia. Acne vulgaris is a chronic inflammatory disease of the skin, specifically the pilosebaceous unit. Inflammation is a critical factor in the development of acne vulgaris. IL-17 is a proinflammatory cytokine that plays a central role in acne vulgaris inflammation. This study aims to obtain information regarding serum 25(OH)D deficiency for IL -17 acne vulgaris. The data collection method was through collecting data from articles related to serum 25-(OH)D deficiency against IL-17 acne vulgaris. The inclusion criteria involved original articles, case-control studies, and review papers on 25(OH)D, IL-17, and acne vulgaris. Vitamin D deficiency can lead to cosmogenesis and inflammatory exacerbations that characterize the acne vulgaris nodulocystic phenotype. The immune response in acne vulgaris is stimulated by the innate immune system via toll-like receptor 2 (TLR2) and adaptive immunity via Th1 lymphocytes. There is evidence that vitamin D inhibits TLR2 expression in monocytes and reduces proinflammatory cytokine production. The most common biomarker in inflammation is IL-17 which was significantly higher in acne vulgaris patients with vitamin D deficiency than in patients with normal vitamin D levels.
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How to Cite
Limarda, I., Moelyadi, F., Aliansa Dimas Tara, A., Rianto, L. and Tjahyanto, T. (2023) “Serum 25-hydroxy vitamin d deficiency against IL 17 acne vulgaris”, Science Midwifery, 10(6), pp. 4814-4821. doi: 10.35335/midwifery.v10i6.1063.
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Autier, P., Gandini, S., & Mullie, P. (2012). A systematic review: Influence of vitamin D supplementation on serum 25-hydroxyvitamin D concentration. In Journal of Clinical Endocrinology and Metabolism (Vol. 97, Issue 8, pp. 2606–2613). https://doi.org/10.1210/jc.2012-1238
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Bostanci, E. I., Ozler, S., Yilmaz, N. K., & Yesilyurt, H. (2018). Serum 25-Hydroxy Vitamin D Levels in Turkish Adolescent Girls with Polycystic Ovary Syndrome and the Correlation with Clinical/Biochemical Parameters. Journal of Pediatric and Adolescent Gynecology, 31(3), 270–273. https://doi.org/10.1016/j.jpag.2017.07.008
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Haydar, A. A., Ismail, N. S., Alsaadi, I. M. T., Tahir, M. M., Hussen, A. N., & Hussen, B. M. (2019). Estimation of serum 25-hydroxy vitamin D and zinc levels in patients with acne vulgaris and their association with disease severity. The Second Scientific Conference for The College of Pharmacy, 51–58.
He, D., Li, H., Yusuf, N., Elmets, C. A., Athar, M., Katiyar, S. K., & Xu, H. (2012). IL-17 mediated inflammation promotes tumor growth and progression in the skin. PLoS ONE, 7(2). https://doi.org/10.1371/journal.pone.0032126
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Jin, W., & Dong, C. (2013). IL-17 cytokines in immunity and inflammation. In Emerging Microbes and Infections (Vol. 2). Nature Publishing Group. https://doi.org/10.1038/emi.2013.58
Karadag, A. S., Ertugrul, D. T., Bilgili, S. G., Takci, Z., Akin, K. O., & Calka, O. (2012). Immunoregulatory effects of isotretinoin in patients with acne. British Journal of Dermatology, 167(2), 433–435. https://doi.org/10.1111/j.1365-2133.2012.10949.x
Kemeriz, F., Tuncer, S. Ç., Acar, E. M., & Tuğrul, B. (2020). Evaluation of 25-hydroxy vitamin D levels and disease severity in patients with acne vulgaris. Dermatologic Therapy, 33(3). https://doi.org/10.1111/dth.13393
Knutsen-Larson, S., Dawson, A. L., Dunnick, C. A., & Dellavalle, R. P. (2012). Acne Vulgaris: Pathogenesis, Treatment, and Needs Assessment. In Dermatologic Clinics (Vol. 30, Issue 1, pp. 99–106). https://doi.org/10.1016/j.det.2011.09.001
Lee, Y. B., Byun, E. J., & Kim, H. S. (2019). Potential role of the microbiome in acne: A comprehensive review. In Journal of Clinical Medicine (Vol. 8, Issue 7). MDPI. https://doi.org/10.3390/jcm8070987
Lenis, A. T., Lec, P. M., & Chamie, K. (2020). Bladder cancer a review. In JAMA - Journal of the American Medical Association (Vol. 324, Issue 19, pp. 1980–1991). American Medical Association. https://doi.org/10.1001/jama.2020.17598
Li, X., Bechara, R., Zhao, J., McGeachy, M. J., & Gaffen, S. L. (2019). IL-17 receptor–based signaling and implications for disease. In Nature Immunology (Vol. 20, Issue 12, pp. 1594–1602). Nature Research. https://doi.org/10.1038/s41590-019-0514-y
Lim, S. K., Ha, J. M., Lee, Y. H., Lee, Y., Seo, Y. J., Kim, C. D., Lee, J. H., & Im, M. (2016). Comparison of vitamin D levels in patients with and without acne: A case-control study combined with a randomized controlled trial. PLoS ONE, 11(8). https://doi.org/10.1371/journal.pone.0161162
McGeachy, M. J., Cua, D. J., & Gaffen, S. L. (2019). The IL-17 Family of Cytokines in Health and Disease. In Immunity (Vol. 50, Issue 4, pp. 892–906). Cell Press. https://doi.org/10.1016/j.immuni.2019.03.021
Mohamed, A. A., Ahmed, E. M. S., Abdel-Aziz, R. T. A., Abdallah, H. H., El-Hanafi, H., Hussein, G., Abbassi, M. M., & el Borolossy, R. (2021). The impact of active vitamin D administration on the clinical outcomes of acne vulgaris. Journal of Dermatological Treatment, 32(7), 756–761. https://doi.org/10.1080/09546634.2019.1708852
Mohiuddin, A. (2019). A Comprehensive Review of Acne Vulgaris. Journal of Clinical Pharmacy, 1(1), 1–17. www.innovationinfo.org
Agak, G. W., Qin, M., Nobe, J., Kim, M. H., Krutzik, S. R., Tristan, G. R., Elashoff, D., Garbán, H. J., & Kim, J. (2014). Propionibacterium acnes induces an IL-17 response in acne vulgaris that is regulated by vitamin A and vitamin D. Journal of Investigative Dermatology, 134(2), 366–373. https://doi.org/10.1038/jid.2013.334
Alhetheli, G., Elneam, A. I. A., Alsenaid, A., & Al-Dhubaibi, M. (2020). Vitamin D levels in patients with and without acne and its relation to acne severity: A case-control study. Clinical, Cosmetic and Investigational Dermatology, 13, 759–765. https://doi.org/10.2147/CCID.S271500
Amatya, N., Garg, A. v., & Gaffen, S. L. (2017). IL-17 Signaling: The Yin and the Yang. In Trends in Immunology (Vol. 38, Issue 5, pp. 310–322). Elsevier Ltd. https://doi.org/10.1016/j.it.2017.01.006
Autier, P., Gandini, S., & Mullie, P. (2012). A systematic review: Influence of vitamin D supplementation on serum 25-hydroxyvitamin D concentration. In Journal of Clinical Endocrinology and Metabolism (Vol. 97, Issue 8, pp. 2606–2613). https://doi.org/10.1210/jc.2012-1238
Aydemir, E. H. (2014). Acne vulgaris. Turk Pediatri Arsivi, 49(1), 13–16. https://doi.org/10.5152/tpa.2014.1943
Bostanci, E. I., Ozler, S., Yilmaz, N. K., & Yesilyurt, H. (2018). Serum 25-Hydroxy Vitamin D Levels in Turkish Adolescent Girls with Polycystic Ovary Syndrome and the Correlation with Clinical/Biochemical Parameters. Journal of Pediatric and Adolescent Gynecology, 31(3), 270–273. https://doi.org/10.1016/j.jpag.2017.07.008
Cannell, J. J., Grant, W. B., & Holick, M. F. (2014). Vitamin D and inflammation. In Dermato-Endocrinology (Vol. 6, Issue 1). Taylor and Francis Inc. https://doi.org/10.4161/19381980.2014.983401
Dawson, A. L., & Dellavalle, R. P. (2013). Acne vulgaris. In BMJ (Online) (Vol. 346, Issue 7907). https://doi.org/10.1136/bmj.f2634
Dreno, B., Gollnick, H. P. M., Kang, S., Thiboutot, D., Bettoli, V., Torres, V., & Leyden, J. (2015). Understanding innate immunity and inflammation in acne: Implications for management. Journal of the European Academy of Dermatology and Venereology, 29(S4), 3–11. https://doi.org/10.1111/jdv.13190
Ebrahim, A. A., Mustafa, A. I., & El-Abd, A. M. (2019). Serum interleukin-17 as a novel biomarker in patients with acne vulgaris. Journal of Cosmetic Dermatology, 18(6), 1975–1979. https://doi.org/10.1111/jocd.12934
El-Hamd, M. A., el Taieb, M. A., Ibrahim, H. M., & Aly, S. S. (2019). Vitamin D levels in acne vulgaris patients treated with oral isotretinoin. Journal of Cosmetic Dermatology, 18(1), 16–20. https://doi.org/10.1111/jocd.12503
Fox, L., Csongradi, C., Aucamp, M., du Plessis, J., & Gerber, M. (2016). Treatment modalities for acne. In Molecules (Vol. 21, Issue 8). MDPI AG. https://doi.org/10.3390/molecules21081063
Haydar, A. A., Ismail, N. S., Alsaadi, I. M. T., Tahir, M. M., Hussen, A. N., & Hussen, B. M. (2019). Estimation of serum 25-hydroxy vitamin D and zinc levels in patients with acne vulgaris and their association with disease severity. The Second Scientific Conference for The College of Pharmacy, 51–58.
He, D., Li, H., Yusuf, N., Elmets, C. A., Athar, M., Katiyar, S. K., & Xu, H. (2012). IL-17 mediated inflammation promotes tumor growth and progression in the skin. PLoS ONE, 7(2). https://doi.org/10.1371/journal.pone.0032126
Heng, A. H. S., & Chew, F. T. (2020). Systematic review of the epidemiology of acne vulgaris. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-62715-3
Jassil, N. K., Sharma, A., Bikle, D., & Wang, X. (2017). Vitamin D binding protein and 25-hydroxyvitamin D levels: Emerging clinical applications. In Endocrine Practice (Vol. 23, Issue 5, pp. 605–613). American Association of Clinical Endocrinologists. https://doi.org/10.4158/EP161604.RA
Jin, W., & Dong, C. (2013). IL-17 cytokines in immunity and inflammation. In Emerging Microbes and Infections (Vol. 2). Nature Publishing Group. https://doi.org/10.1038/emi.2013.58
Karadag, A. S., Ertugrul, D. T., Bilgili, S. G., Takci, Z., Akin, K. O., & Calka, O. (2012). Immunoregulatory effects of isotretinoin in patients with acne. British Journal of Dermatology, 167(2), 433–435. https://doi.org/10.1111/j.1365-2133.2012.10949.x
Kemeriz, F., Tuncer, S. Ç., Acar, E. M., & Tuğrul, B. (2020). Evaluation of 25-hydroxy vitamin D levels and disease severity in patients with acne vulgaris. Dermatologic Therapy, 33(3). https://doi.org/10.1111/dth.13393
Knutsen-Larson, S., Dawson, A. L., Dunnick, C. A., & Dellavalle, R. P. (2012). Acne Vulgaris: Pathogenesis, Treatment, and Needs Assessment. In Dermatologic Clinics (Vol. 30, Issue 1, pp. 99–106). https://doi.org/10.1016/j.det.2011.09.001
Lee, Y. B., Byun, E. J., & Kim, H. S. (2019). Potential role of the microbiome in acne: A comprehensive review. In Journal of Clinical Medicine (Vol. 8, Issue 7). MDPI. https://doi.org/10.3390/jcm8070987
Lenis, A. T., Lec, P. M., & Chamie, K. (2020). Bladder cancer a review. In JAMA - Journal of the American Medical Association (Vol. 324, Issue 19, pp. 1980–1991). American Medical Association. https://doi.org/10.1001/jama.2020.17598
Li, X., Bechara, R., Zhao, J., McGeachy, M. J., & Gaffen, S. L. (2019). IL-17 receptor–based signaling and implications for disease. In Nature Immunology (Vol. 20, Issue 12, pp. 1594–1602). Nature Research. https://doi.org/10.1038/s41590-019-0514-y
Lim, S. K., Ha, J. M., Lee, Y. H., Lee, Y., Seo, Y. J., Kim, C. D., Lee, J. H., & Im, M. (2016). Comparison of vitamin D levels in patients with and without acne: A case-control study combined with a randomized controlled trial. PLoS ONE, 11(8). https://doi.org/10.1371/journal.pone.0161162
McGeachy, M. J., Cua, D. J., & Gaffen, S. L. (2019). The IL-17 Family of Cytokines in Health and Disease. In Immunity (Vol. 50, Issue 4, pp. 892–906). Cell Press. https://doi.org/10.1016/j.immuni.2019.03.021
Mohamed, A. A., Ahmed, E. M. S., Abdel-Aziz, R. T. A., Abdallah, H. H., El-Hanafi, H., Hussein, G., Abbassi, M. M., & el Borolossy, R. (2021). The impact of active vitamin D administration on the clinical outcomes of acne vulgaris. Journal of Dermatological Treatment, 32(7), 756–761. https://doi.org/10.1080/09546634.2019.1708852
Mohiuddin, A. (2019). A Comprehensive Review of Acne Vulgaris. Journal of Clinical Pharmacy, 1(1), 1–17. www.innovationinfo.org